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TRANS; meaning "across"

DERMAL; meaning "the skin"

Although we think of the primary purpose of the skin as a barrier to keep things out of the body, scientists have known for at least 2 centuries that certain compounds have the ability to cross the layers of the skin and obtain access to blood vessels and the general circulation. Modern medicine has responded with the development of methods to deliver drugs transdermally for therapeutic use as an alternative to traditional routes.

Why would one need to go through the trouble of formulating a transdermal when perhaps a simple tablet would do?

Well, the advantages of transdermal drug delivery systems speak for themselves and include avoidance of side effects, avoidance of the gastrointestinal tract and hepatic first-pass biotransformation and metabolism, control of absorption, availability of multiple skin sites to avoid local irritation and toxicity, and improved compliance. The result is a wider range of therapeutic options for physicians to use in optimizing their patients care.

Despite these facts, drug manufacturers have not been fast to bring these products to market. Currently there are only 13 transdermal medications available in Canada, yet studies have shown many more drugs to actually be effective in transdermal preparations.

This is where Central Pharmacy’s specialty transdermal compounding service comes in. Through the use of a specially compounded Pluronic-Lecithin-Organogel (PLO gel) we are able to formulate transdermal preparations of a large variety of drugs. The PLO gel serves as a carrier for the drug and "takes" it across the skin where it can be taken up by the bloodstream to penetrate deep into the affected tissues. One theory is that the PLO gel slightly disorganizes the structure of the skin, and thus, permits the permeation of various substances.

The following are examples of transdermal preparations which we have compounded in the past. If you feel that you or someone you know would benefit from our transdermal compounding service, or would just like to find out more about this unique delivery route, please contact us. We will be happy to discuss your questions and concerns.


Examples of Transdermal Compounds

bul.gif (507 bytes)Non Steroidal Anti-inflammatory Drugs (NSAIDS) (particularly useful for those who suffer from stomach upset due to NSAIDS or those with allergies to NSAIDS)

bul.gif (507 bytes)Anti-nauseants

bul.gif (507 bytes)Narcotic Analgesics

bul.gif (507 bytes)Muscle Relaxants

bul.gif (507 bytes)Corticosteroids